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Abstract #4494

Pulsed Saturation Transfer for Quantifying CEST in the Presence of MT

Kimberly L. Desmond1, Greg J. Stanisz1,2

1Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

The quantification of the CEST effect in-vivo is complicated by the presence of immobile macromolecules, which additionally results in a large MT effect. The MT component has a significant impact on the magnitude of the CEST effect, which reduces the validity of asymmetry-based techniques. We propose a method by which the parameters for both CEST and MT pool can be determined independently by fitting a three pool model to data from a pulsed saturation transfer experiment. This method is tested on a set of three phantoms, containing 1M ammonium chloride, 2% agar, and both compounds combined.