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Abstract #4493

Intrinsic Connectivity Contrast: A Novel Contrast Mechanism for Investigating a Wide Range of Brain Disorders

R. Todd Constable1, Yuko Hara2, Nallakkandi Rajeevan1, Fuyuze Tokoglu1, Xenios Papademetris1

1Diagnostic Radiology, Yale University, New Haven, CT, USA; 2Biomedical Engineering, Yale University, New Haven, CT, USA

A novel contrast mechanisms based on resting state connectivity BOLD fMRI data is presented which delineates areas in the gray matter that exhibit altered connectivity relative to control subjects. This approach is applicable to any neurodegenerative disorder and provides a new tool for localizing disrupted tissues.