Abstract #4493

Intrinsic Connectivity Contrast: A Novel Contrast Mechanism for Investigating a Wide Range of Brain Disorders

R. Todd Constable¹, Yuko Hara², Nallakkandi Rajeevan¹, Fuyuze Tokoglu¹, Xenios Papademetris¹

¹Diagnostic Radiology, Yale University, New Haven, CT, USA; ²Biomedical Engineering, Yale University, New Haven, CT, USA

A novel contrast mechanisms based on resting state connectivity BOLD fMRI data is presented which delineates areas in the gray matter that exhibit altered connectivity relative to control subjects. This approach is applicable to any neurodegenerative disorder and provides a new tool for localizing disrupted tissues.