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Abstract #4609

Correction of Off-Resonance Effects in Multi-Component Driven Equilibrium Single Pulse Observation of T1 and T2 (McDESPOT)

Sean CL Deoni1

1Centre for Neuroimaging Sciences, London, UK

mcDESPOT is a promising new approach to whole-brain multi-component relaxometry. However, as the method utilizes data acquired using the rapid steady-state free-precession imaging sequence, it is sensitive to off-resonance effects leading to substantive errors in the derived myelin water fraction and relaxation time estimates. Here we suggest a simple approach allowing the near complete removal of these artifacts and demonstrate the efficiency of the technique in vivo.