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Abstract #4668

Simulation of Nasal Air Flow from MRI Data a Feasibility Study

Arthur Peter Wunderlich1, Barbara Doll2, Marc Scheithauer3, Wolfgang Freund1, Karsten Urban4, Ulrich Simon2

1Diagnostic and Interventional Radiology, Univ.-Clinic Ulm, Ulm, Baden-Wrttemberg, Germany; 2Scientific Computing Centre, University Ulm, Ulm, Baden-Wrttemberg, Germany; 3Otolaryngology, Univ.-Clinic Ulm, Ulm, Baden-Wrttemberg, Germany; 4Institue for Numerical Mathematics, University Ulm, Ulm, Baden-Wrttemberg, Germany

To study the feasibility of simulating the nasal air flow in inspiration and expiration with finite volume methods, we investigated one healthy subject with high-resolution MRI during breathing of a) room air and b) menthol. In a third experiment, the same sequence was used c) after inhalation of xylometazoline, a widely used decongestant drug. Nasal airways were segmented from MRI data and inspiratory as well as expiratory flow in all three conditions was simulated with mathematical methods. Simulations reveal pressure-flow-curves separately for both conchae as well as flow distribution in nasal airways and their dependence on medication.