Imaging Solutions I: Structural and Functional Imaging

Wiesje M. van der Flier¹

MRI has an increasingly large role in the clinical work-up of dementia. In the new research criteria, atrophy of the medial temporal lobe is mentioned as one of the diagnostic criteria for AD, but norm values are still awaited. Mixed disease (i.e. combination with vascular disease) remains a challenge, as there are no diagnostic guidelines available. MRI measures hold promise as markers of disease progression and can potentially be used as outcome measures in trials. The heterogeneity of AD is increasingly acknowledged. MRI may prove valuable to describe endophenotypes of AD, both in terms of structural and functional brain changes