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Abstract #0003

Imaging Solutions II: Molecular Imaging

Louise van der Weerd1

1Leiden University Medical Centre, Leiden, Netherlands

The development of molecular imaging techniques for in vivo assessment of beta-amyloid accumulation in the ageing brain is an important and active area of research in AD. Numerous ligands have been developed with affinity for beta-amyloid, based on beta-amyloid peptide, monoclonal antibody fragments, or small peptides, which were functionalized with iron oxide particles or gadolium chelates. Alternatively, amyloid plaques have been labeled with small molecules containing a 19F atom and visualized using 19F MRI. Up to now, the only compounds that are in use for clinical imaging are nuclear medicinebased amyloid labeling tracers.

(Admission limited to Clinical Intensive Course registrants only)
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