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Abstract #0040

MR Contrast from Ascorbic Acid (Vitamin C) in Phantoms and in Vivo

Christopher D. Lascola1, Talaignair Venkatraman1, Bjorn Engstrom1, Haichen Wang1

1Department of Radiology and Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, United States

: L-ascorbic acid (vitamin C) is the most abundant intracellular antioxidant and an essential co-factor. Intracellular levels of ascorbic acid (AA) are remarkably high, where concentrations may exceed 10-30 mM. In this study, we show that AA in solution produces significant changes in T2 and T2* relaxivity at physiologically relevant concentrations. These results raise two important possibilities: first, that endogenous AA may be an important contributor to native T2 and T2* contrast in CNS and other tissues; and second, that both oxidized and reduced forms of ascorbic acid may have utility as novel MR contrast probes.