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Abstract #0041

Hyperpolarized 89Y Complexes as PH Sensitive NMR Probes

Ashish Kumar Jindal1, Matthew E. Merritt1, Eul Hyun Suh1, Craig R. Malloy1,2, Alan Dean Sherry1,3, Zoltan Kovacs1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Veterans Affairs, North Texas Health Care System, Dallas, TX, United States; 3Department of Chemistry, University of Texas at Dallas, Richardson, TX, United States

Hyperpolarization followed by fast dissolution provides tremendous gains in SNR in both NMR and MRI experiments, but a primary bottleneck in its application is the T1 decay of the magnetization in the liquid state. Due to its long T1, hyperpolarized 89Y makes an excellent candidate as an in vivo imaging agent. Here we report the chemical shift dependence upon pH for two hyperpolarized 89Y complexes and clearly demonstrate how such complexes can be used as sensitive spectroscopy/imaging probes to measure pH.