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Abstract #0054

Analysis of MRI Data Monitoring the Treatment of Polycystic Kidney Disease in a Preclinical Mouse Model

Stathis Hadjidemetriou1, Wilfried Reichardt1, Juergen Hennig1, Martin Buechert2, Dominik von Elverfeldt1

1Department of Diagnostic Radiology, University Hospital Freiburg, Freiburg, Germany; 2MRDAC, Freiburg, Germany

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the growth of kidney cysts and the eventual kidney failure in humans. A treatment for ADPKD is not yet available. Treatment development involves preclinical studies with a mouse ADPKD model. Such mice have been monitored longitudinally with high field animal MRI. In this work the mouse kidneys are segmented with an unsupervised, reliable, and reproducible method. A region of interest is identified and analyzed for its statistics and for kidney geometry. This information is incorporated into the graph cuts algorithm that delineates the kidneys. Extensive validation is presented.