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Abstract #0055

Effects of Smoking on Mouse Adipose Tissue Volumes Measured by IDEAL at 11.7T

David Johnson1, Jiarui Lian1, Mohamed El-Mahdy1, Jay L. Zweier1

1Heart and Lung Research Institute, Ohio State University, Columbus, OH, United States

An imaging technique was developed to produce uniform, robust fat-water separation in mice at 11.7T using Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation method (IDEAL). Cigarette smoking (CS) C57BL/6 mice had less body weight and subcutaneous adipose tissue volumes as compared to controls. The volumes of muscle and other non-adipose tissues were not different between CS and control mice, supporting the hypothesis of a selective reduction in fat storage due to smoking.