Thomas Joseph Re1,2, Mirium Klauss3, Andreas Lemke4, Frederik B. Laun2, Dirk Simon5, Riccardo Manfredi1, Roberto Pozzi Mucelli1, Stefan Delorme2, Bram Stieltjes2
1Radiology, University of Verona, Verona, Italy; 2Radiology, DKFZ, Heidelberg, BW, Germany; 3Radiology, University of Heidelberg, Heidelberg, BW, Germany; 4MS Computer Assisted Clinical Medicine, University of Heidelberg; 5Software Development for Integrated Diagnostics and Therapy, DKFZ, Heidelberg, BW, Germany
Maps of IVIM model derived perfusion fraction f (f-maps) of the pancreas show potential for the identification of pancreatic adenocarcinoma lesions which appear hypointense in these images. Unfortunately, since bile and pancreatic ducts also appear as hypointense in f-maps, their presence adjacent to tumors can lead to tumor delineation errors. A novel approach which automatically segmented vessels and ducts in the f-maps based on integrated diffusion coefficient D data was tested in 43 patients and proved to be superior to both the ADC or f-map for tumor delineation.