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Abstract #0094

Higher Pre-Treatment Apparent Diffusion Coefficient Predicts Poorer Disease Survival in Patients with Colorectal Hepatic Metastasis

Henry Ho Ching Tam1, David J. Collins2, Gina Brown1, Ian Chau3, David Cunningham3, Martin O. Leach2,
Dow-Mu Koh1

1Department of Radiology, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; 2CRUK-EPSRC Cancer Imaging Centre, Institute of Cancer Research, Sutton, Surrey, United Kingdom; 3Department of Medical Oncology (Gastrointestinal), Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

We report the use of DW-MRI for assessing response to chemotherapy and long-term outcome in patients with colorectal hepatic metastasis. Non-responders were found to have a higher pre-treatment apparent diffusion coefficient (ADC). High pre-treatment ADC was also associated with a shorter progression free survival time, independent of response to chemotherapy and other prognostic factors. This study demonstrates the potential of DW-MRI as a biologically relevant response and prognostic biomarker.