Henry Ho Ching Tam1, David J. Collins2,
Gina Brown1, Ian Chau3, David Cunningham3,
Martin O. Leach2,
1Department of Radiology, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; 2CRUK-EPSRC Cancer Imaging Centre, Institute of Cancer Research, Sutton, Surrey, United Kingdom; 3Department of Medical Oncology (Gastrointestinal), Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
We report the use of DW-MRI for assessing response to chemotherapy and long-term outcome in patients with colorectal hepatic metastasis. Non-responders were found to have a higher pre-treatment apparent diffusion coefficient (ADC). High pre-treatment ADC was also associated with a shorter progression free survival time, independent of response to chemotherapy and other prognostic factors. This study demonstrates the potential of DW-MRI as a biologically relevant response and prognostic biomarker.