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Abstract #0095

Value of Diffusion Weighted Imaging (DWI) as an Early Imaging Biomarker for Prediction of Therapy Effect in Patients with Colorectal Metastases Following Selective Internal Radiotherapy (SIRT)

Martin Zeile1, Christian Wybranski1, David Loewenthal1, Maciej Pech1, Frank Fischbach1, Ricarda Ruehl1, Holger Amthauer1, Jens Ricke1, Oliver Dudeck1

1Clinic for Radiology and Nuclear Medicine, University Clinic Magdeburg, Magdeburg, 39120, Germany

Clinical studies revealed the potential of diffusion weighted imaging (DWI) as a biomarker for predicting tumor response. 41 colorectal liver metastases in 18 patients who underwent SIRT were examined before, 1 to 3 days after and 6 weeks following radioembolization by MRI including DWI. Lesions were categorized in responding (RL) and non-responding (NRL) according to change in tumor volume after 6 weeks. On early MRI, NRL showed no change in apparent diffusion coefficient (ADC), while a significant decrease in ADC was noted for RL (p<0.0001). DWI was capable of predicting therapy response in patients with colorectal liver metastases following radioembolization.