A. Shukla-Dave1, N. Y. Lee1, J.
F. Jansen1, H. T. Thaler1, H. E. Stambuk1,
M. G. Fury1, E. Sherman1, S. Karimi1, Y.
Wang1, D. Kraus1, S. G. Patel1, J. P. Shah1,
D. G. Pfister1, J. A. Koutcher1
one of the greatest challenges in the management of head and neck squamous
cell carcinoma (HNSCC) is to identify and select prior to therapy, patients
who are likely to fail the chosen treatment, for consideration of alternative
risk adjusted therapies. The present study assesses whether pretreatment
DCE-MRI parameters can reliably predict outcome in HNSCC patients with nodal
metastases. DCE-MRI was performed in 74 patients studied prior to
chemotherapy and radiation therapy (n=61) or surgery (n=13). The results suggest that skewness of Ktrans
was the strongest predictor of outcome in
HNSCC patients with stage IV disease.