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Abstract #0155

Intrinsic Susceptibility-Weighted MRI to Assess the Response of Combretastatin-A4-Phosphate During Radiotherapy for Prostate Cancer

Roberto Alonzi1, Peter J. Hoskin1, N Jane Taylor2, Quan S. Ng1, Henry Mandeville1, Uma Patel1, J James Stirling2, James A. d'Arcy3, David J. Collins3, Martin O. Leach3, Anwar R. Padhani2

1Marie Curie Research Wing, Mount Vernon Cancer Centre, Northwood, London, United Kingdom; 2Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Northwood, London, United Kingdom; 3CRUK-EPSRC Cancer Imaging Centre, Institute of Cancer Research & Royal Marsden Hospital, Sutton, Surrey, United Kingdom

Radiotherapy may be delivered in combination with vascular targeting agents. The performance of imaging biomarkers for response assessment may be compromised by the differing or conflicting effects between drug and radiation on tumor tissues. Previous studies have shown that DCE-MRI only partially describes the vascular changes in this setting. This study has evaluated the ability for Intrinsic Susceptibility-Weighted MRI to assess the response of Combretastatin-A4-Phosphate during radiotherapy for prostate cancer. We conclude that R2* has the potential to be an alternative, clinically useable, response biomarker for assessment of vascular disruptive therapy in combination with radiotherapy in prostate cancer.