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Abstract #0161

Assessment of Reflux-Induced Esophageal Compliance Using Concurrent Magnetic Resonance Imaging and High-Resolution Manometry

Jelena Curcic1, Andreas Steingoetter1,2, Reto Treier1, Elad Kaufman3,4, Zsofia Forras-Kaufman3, Mark Fox3,5, Werner Schwizer3, Michael Fried3, Peter Boesiger1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 2Institute of Radiology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany; 3Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; 4Institute for Surgical Pathology, University Hospital Zurich, Zurich, Switzerland; 5Nottingham Digestive Diseases Centre and Biomedical Research Unit, University Hospital, Nottingham, United Kingdom

The prevalence of the gastro-esophageal reflux disease (GERD) amounts to 10% to 20% worldwide and is higher in the western than in the eastern countries. However, the influence of aggressive gastric acid on the esophageal muscles is poorly described. Concurrent magnetic resonance imaging (MRI) and high-resolution manometry (HRM) were used to assess the esophageal compliance induced by reflux events in healthy volunteers and GERD patients. The results show significant esophageal distention difference but only small pressure difference between two groups. This indicates that esophageal distention may be a sensitive parameter for assessment of esophageal compliance even without invasive manometry measurement.

17:30 Introduction: Female Pelvis
Georg M. Bongartz