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Abstract #0162

Evaluation of Magnetic Resonance Diffusion and Spectroscopy Measurements as Predictive Biomarkers in Stage 1 Cervical Cancer

Maria A. Schmidt1, Geoffrey S. Payne1, Veronica A. Morgan1, Sharon Giles1, Jane Bridges2, Thomas Ind2, Nandita deSouza1

1CRUK/ESPRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, MRI Unit , Sutton, England, United Kingdom; 2Gynaecological Oncology, Royal Marsden NHS Foundation Trust and Chelsea & Westminster Hospital, London, United Kingdom

This study applies functional MRI techniques (DWI and MRS) to cervical tumors with different histological characteristics (type, degree of differentiation and presence or absence of lymphovascular invasion) in order to investigate their potential as predictive biomarkers. There was a statistically significant difference between the ADC of well/moderately differentiated tumors compared with poorly differentiated tumors. There was no significant difference between the ADCs of the tumors when separated by other characteristics. There was no significant difference in tCho between any of the tumor categories investigated and no correlation between tumor ADC and tCho.