Kieren Grant Hollingsworth1, David Emerys
Jones2,
1Newcastle Magnetic Resonance Centre, Newcastle
University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; 2Institute
of Cellular Medicine, Newcastle University, Newcastle upon Tyne, Tyne and
Wear, United Kingdom; 3Institute for Ageing and Health, Newcastle
University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
Studies
of muscle metabolism in chronic fatigue syndrome (CFS) have often had
contradictory results and suggested the presence of mixed phenotypes. Recent
evidence has suggested that cardiac output is adversely affected in CFS. 12 female CFS/ME patients and 8 controls
were recruited. Cardiac phosphorus spectroscopy, muscle exercise phosphorus
spectroscopy and impedance cardiography were acquired. Cardiac PCr/ATP ratio
was related to changes in cardiac index on standing and reduced PCr/ATP ratio
was found to correlate with impaired oxidative function (half-times for PCr
and ADP recovery). Cardiac
spectroscopy was found to be useful in stratifying oxidative function in CFS.
Keywords