Xiao-Hong Zhu1, Yi Zhang1, Wei Chen1
1Center for Magnetic Resonance
Research, Department of Radiology,,
Heart, similar to brain, is a highly aerobic organ which consumes a large portion of oxygen utilized by the entire body. The myocardial oxygen metabolism provides essential energy for performing myocyte contraction/relaxation and maintaining normal cardiac functions. It is, thus, important to develop an in vivo MR imaging approach capable of noninvasively imaging the myocardial oxygen metabolic rate (MVO2). Recently, high-field in vivo 17O MRS imaging (MRSI) has been applied to imaging the rat brain oxygen metabolism. In this study, we exploit the feasibility of the 17O approach for imaging rat MVO2 at 9.4T with a brief inhalation of 17O-labeled oxygen gas under basal and workload conditions.