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Abstract #0174

Myocardial Lipids and Myocardial Function in Insulin Resistant Population.

Martin Krssak1,2, Yvonne Winhofer2, Christian Gbl2, Martin Bischof2, Gert Reiter3, Alexandra Kautzky-Willer2, Anton Luger2, Michael Krebs2, Christian Anderwald2

1Radiology, Medical University of Vienna, Wien, Austria; 2Internal Medicine III, Medical University of Vienna, Wien, Austria; 3Siemens Healthcare Austria, Graz, Austria

Myocardial lipid accumulation and myocardial function were measured by 1H MR spectroscopy and imaging in a group of non-diabetic insulin sensitive and metabolically matched non-diabetic insulin resistant women. No differences were found between these two groups, but hampered myocardial function and increased myocardial lipid accumulation was found in a group patients with type 2 diabetic mellitus, who served as a negative controls. Our results suggest that increased myocardial lipid content and restricted myocardial capacity are not linked to insulin resistance per se, but might develop after the manifestation of type-2 diabetes.