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Abstract #0199

Evaluation of Emphysema Progression in Chronic Obstructive Pulmonary Disease (Copd); 3He 3D Adc Measurements Compared with Ct and Lung Function Test, Preliminary Results.

Frederik Hengstenberg1,2, Torsten Dorniok1, Sergei Karpuk3, Jrgen Vestbo2, Rahim Rizi4, Per keson1, Peter Magnusson1, Lise Vejby Sgaard1

1Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 2Department of Cardiology and Respiratory Medicine, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 3Institute of Physics, University of Mainz, Mainz, Germany; 4Department of Radiology, University of Pennsylvania, PA, United States

There is a need for developing a more sensitive biomarker for monitoring progression of pulmonary emphysema in COPD. In this study with 20 COPD patients and 5 healthy control subjects the use of the 3He apparent diffusion coefficient (ADC) in assessing progression was investigated in a one year longitudinal study comparing ADC measurements, CT densitometry and lung function tests. In a subgroup of emphysema patients a significant increase of ADC was detected, reflecting disease progression.