Sean Fain1, Rafael O'Halloran2, Eric Peterson3, James Holmes4
1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States; 2Radiology, Stanford University, Stanford, CA, United States; 3Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States; 4Applied Science Lab, GE Healthcare, Madison, WI, United States
Assessment of lung function in pediatrics poses significant challenges due to variable ability to cooperate with respiratory maneuvers. Radial dynamic 3D imaging using multi-echo VIPR (ME-VIPR) acquisition with HP He-3 and I-HYPR reconstruction is used in a protocol designed to minimize breath-hold time for whole lung coverage with good isotropic resolution, and sufficient temporal resolution to adapt to the subject's ability to perform respiratory maneuvers. Diffusion-weighted MRI with HP He-3 MRI also provides a means to assess microstructure of the lung parenchyma without ionizing radiation. Preliminary results in 40 pediatric subjects at-risk for asthma are presented.