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Abstract #0205

Dynamic Oxygen-Enhanced MRI in Patients with Pulmonary Arterial Hypertension

Olaf Dietrich1, Daniel Maxien, Sven Thieme, Maximilian F. Reiser1, Konstantin Nikolaou

1Josef Lissner Laboratory for Biomedical Imaging, Department of Clinical Radiology, LMU Ludwig Maximilian University of Munich, Munich, Germany

Dynamic oxygen-enhanced MRI (O2-MRI) of the lung was applied in 11 healthy volunteers and in 20 patients with pulmonary arterial hypertension (PAH). Data was evaluated pixelwise by fitting a piecewise exponential model function with 4 parameters (relative enhancement, signal delay, wash-in/out times) to the signal time course. The individual parameter distributions were compared between volunteers and patients. The median values of the determined parameters were similar in both groups, but the ranges (16th to 84th percentile) of relative signal enhancement, signal delay and wash-out time constant were significantly increased in PAH patients.