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Abstract #0281

7T DTI in Mild Chronic Traumatic Brain Injury: Assessment of the Superior Longitudinal Fasciculus and Cingulum Bundle

Dustin Cunningham1, Seongjin Choi1, John Corrigan2, Jennifer Bogner2, W Mysiw2, Cherian Renil Zachariah1, Michael V. Knopp1, Petra Schmalbrock1

1Radiology, The Ohio State University, Columbus, OH, United States; 2Physical Medicine and Rehab, The Ohio State University, Columbus, OH, United States

In order to differentiate mild chronic traumatic brain injury (TBI) patients from age matched healthy controls we explored the use of 7T diffusion tensor imaging (DTI) of the cingulum bundle (CB) and the superior longitudinal fasciculus (SLF). We observed qualitative and quantitative differences between the two groups that included statistically different fractional anisotropy (FA) values for a ROI placed in the CB and visually different fibers for the SLF in the right hemisphere of TBI patients. Our results are encouraging because they support the idea that DTI may be useful as a tool to diagnose and characterize mild chronic TBI.