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Abstract #0282

Functional and Structural Connectivity of Default Mode Network in Patients with Schizophrenia: A Combined Resting-State FMRI and Diffusion Spectrum Imaging Study

Su-Chun Huang1, Fang-Chen Yeh2,3, Hai-Go Hwu4, Chih-Min Liu4, Chen-Chung Liu4, Fa-Hsuan Lin5, Wen-Yih Isaac Tseng, 2,5

1Institution of Medical Engineering, Taipei, Taiwan; 2National Taiwan University College of Medicine, Center for Optoelectronic Biomedicine, Taipei, Taiwan; 3Carnegie Mellon University , Department of Biomedical Engineering, Pittsburgh, PA, United States; 4National Taiwan University Hospital, Department of Psychiatry, Taipei, Taiwan; 5National Taiwan University, Institute of Biomedical Engineering, Taipei, Taiwan

With the combination of resting-state fMRI and DSI, the relationships between FC, SC and clinical PNASS scores were investigated in patients with schizophrenia. Significant correlations between FC and PNASS scores were found in three pairs of DMN, namely the IPL-IPR, the IPL-PCCR, and the IPR-PCCL pairs. However, the SC showed no significant correlation with PNASS score. Our results suggest that FC of DMN associates with the severity of the clinical symptoms more strongly than SC. Moreover, after ignoring three drug-nave patients, the SC between IPR and PCCL was negatively correlated with FC, implying that alteration of FC might down regulate SC. To clarify this, a longitudinal study is warranted to study the interactions between FC and SC, and their effects on clinical symptoms during the disease course.