Su-Chun Huang1, Fang-Chen Yeh2,3,
Hai-Go Hwu4, Chih-Min Liu4, Chen-Chung Liu4,
Fa-Hsuan Lin5, Wen-Yih Isaac Tseng, 2,5
1Institution of Medical Engineering,
Taipei, Taiwan; 2National Taiwan University College of Medicine,
Center for Optoelectronic Biomedicine, Taipei, Taiwan; 3Carnegie
Mellon University , Department of Biomedical Engineering, Pittsburgh, PA,
United States; 4National Taiwan University Hospital, Department of
Psychiatry, Taipei, Taiwan; 5National Taiwan University, Institute
of Biomedical Engineering, Taipei, Taiwan
With
the combination of resting-state fMRI and DSI, the relationships between FC,
SC and clinical PNASS scores were investigated in patients with
schizophrenia. Significant correlations between FC and PNASS scores were
found in three pairs of DMN, namely the IPL-IPR, the IPL-PCCR, and the
IPR-PCCL pairs. However, the SC showed no significant correlation with PNASS
score. Our results suggest that FC of DMN associates with the severity of the
clinical symptoms more strongly than SC. Moreover, after ignoring three
drug-nave patients, the SC between IPR and PCCL was negatively correlated
with FC, implying that alteration of FC might down regulate SC. To clarify
this, a longitudinal study is warranted to study the interactions between FC and
SC, and their effects on clinical symptoms during the disease course.
Keywords