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Abstract #0306

In Vivo Evidence of Axonal Transport Perturbation in a Mouse Model of Tauopathy : A Track-Tracing Memri Study

Anne Bertrand1,2, Minh D. Hoang2, Dmitry Novikov2, Susan Pun2, Pavan Krishnamurthy1, Hameetha Banu1, Benjamin Winthrop Little2, Einar M. Sigurdsson1, Youssef Zaim Wadghiri2

1Physiology and Neuroscience, NYU Medical Center, New York, NY, United States; 2Radiology, NYU Medical Center, New York, NY, United States

We report a track-tracing MEMRI in a mouse model of tauopathy (P301L line). We compared transgenic and wild-type animals at an early stage (6 month-old), using a long timeframe protocol (9 consecutive MR examinations for each mice) and a mathematical modelization of axonal transport using a drift-diffusion model. We show that P301L mice display significant differences in 2 parameters of axonal transport : the value of the peak of Mn, and the time of the peak of Mn. We also observed trends in drift velocity V, leakage rate λ and apparent speed of Mn transport that were smaller in TG mice that in WT. This provides the first in vivo evidence of axonal transport impairment assessed by MRI in a model of tauopathy.