Abstract #0307
Logan
Graphical Analysis for Quantitative Evaluation of Calcium Channel Activity in
the Pituitary Gland Using Manganese-Enhanced MRI (MEMRI)
Christoph Leuze1,2, Ichio Aoki1,
Yuichi Kimura1
1National Institute of Radiological
Sciences, Chiba, Japan;
2Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Sachsen,
Germany
Logan graphical analysis (LGA),
common in PET for the quantitative analysis of neuroreceptors, was performed
with MRI to investigate the influence of stimulants and inhibitors on the
Calcium channel activity in animal brain tissue. In this study LGA is applied
to data which was acquired by measuring the concentrations of Manganese (Mn)
in tissue and blood over a certain period of time after Mn-injection. The Mn
uptake between experiments was varied by the excitatory neurotransmitter
Glutamate and the Calcium channel blocker Verapamil. The analysis
successfully delivers information about the varying in- and outflow of Mn
from blood to tissue.
