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Abstract #0309

Quantitative Multi-Parametric Assessment of a Radiation-Induced Encepholodysplasia CNS Model Using Magnetic Resonance Imaging

Shigeyoshi Saito1,2, Kazuhiko Sawada3, Xue-Zhi Sun, Kai-Hsiang Chuang4, Tetsuya Suhara, Iwao Kanno, Ichio Aoki

1Tohoku Univeristy, Sendai, Miyagi, Japan; 2National Institute of Radiological Sciences, Chiba, Japan; 3Tsukuba International University, Tsukuba, Ibaraki, Japan; 4Singapore Bioimaging Consortium, Singapore

In vivo evaluation of radiation damage in the CNS is important for the assessment and treatment. In this study, we non-invasively assessed neonatal brain of development disorder induced by prenatal x-ray exposure with quantitative MRI. Changes in T1 induced by intracellular Mn2+ contrast agents were observed in the CNS of normal and radiation irradiated rats. Diffusion and transverse relaxation time (T2) were assessed. For the assessment of acquired images, the rats were killed humanely for a histological study with Hematoxylin-Eosin (cell density and necrotic changing), Activated Caspase-3 (apoptotic changing), and Glial fibrillary acidic protein (astrogliosis).