Shigeyoshi Saito1,2, Kazuhiko Sawada3,
Xue-Zhi Sun, Kai-Hsiang Chuang4, Tetsuya Suhara, Iwao Kanno, Ichio
Aoki
1Tohoku Univeristy, Sendai, Miyagi,
Japan; 2National Institute of Radiological Sciences, Chiba, Japan;
3Tsukuba International University, Tsukuba, Ibaraki, Japan; 4Singapore
Bioimaging Consortium, Singapore
In
vivo evaluation of radiation damage in the CNS is important for the
assessment and treatment. In this study, we non-invasively assessed neonatal
brain of development disorder induced by prenatal x-ray exposure with quantitative
MRI. Changes in T1 induced by intracellular Mn2+ contrast agents were
observed in the CNS of normal and radiation irradiated rats. Diffusion and
transverse relaxation time (T2) were
assessed. For the assessment of acquired images, the rats were killed
humanely for a histological study with Hematoxylin-Eosin (cell density and
necrotic changing), Activated Caspase-3 (apoptotic changing), and Glial
fibrillary acidic protein (astrogliosis).
Keywords