Abstract #0310

Induced T1, T2* and Phase Changes Following Manganese Systemic Administration at 14.1T

Rajika Maddage¹, Jos P. Marques^2,3, Rolf Gruetter^2,4

¹Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne , Lausanne, Switzerland; ²Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; ³Department of Radiology , University of Lausanne, Lausanne, Switzerland; ⁴Department of Radiology, University of Lausanne and Geneva, Switzerland

Manganese enhanced MRI studies have been increasingly used in animal neuroimaging thanks to its T₁ shortening properties and enhancement specificity. The aim of this study was to quantitatively evaluate at 14.1T the dynamic evolution of T₁, T₂^* in different regions of the rat brain during manganese systemic administration and to access its impact on phase imaging. Preliminary results show enhancement in the hippocampus and cortex in phase imaging making it a potential tool to trace Mn²⁺ enrichment.