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Abstract #0320

Composition of Fatty Acids in Adipose Tissue by In Vivo 13C MRS at 7T

Ivan Dimitrov1, Jimin Ren2, Deborah Douglas2, Jeannie Davis2, A Dean Sherry2, Craig R. Malloy2

1Philips Medical Systems, Cleveland, OH, United States; 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

The risk of many chronic diseases may be influenced by the composition of fatty acids in adipose tissue, particularly the ratio of saturated to unsaturated fats and the ratio of omega-6 to omega-3 fats. However, the chemical shift dispersion of 1H MRS is not sufficient for full analysis of chemical composition. Broadband proton-decoupled 13C NMR spectra of subcutaneous adipose tissue were obtained in healthy subjects. After corrections for T1 and nuclear Overhauser effects, the poly-, mono-, and saturated fat composition was 18%, 49%, and 32%, respectively. 13C NMR is a rich source of information about adipose composition in humans.