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Abstract #0321

Influence of Regional Macromolecule Baseline on the Quantification of Neurochemical Profile in Rat Brain

Lijing Xin1, Vladimir Mlynrik1, Hongxia Lei2, Rolf Gruetter, 12

1Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 2Department of Radiology, University of Lausanne, Lausanne, Switzerland

The aim of present study was to measure the macromolecule baselines from four different volumes of interest including cortex, hippocampus, striatum and a mixture of brain structures, and then to assess their influence on the quantification of metabolites. Minor differences were found between the macromolecules acquired from specific regions and a large volume containing various cerebral structures. A slight variability in the shape of the macromolecule baseline introduced by data processing can affect calculated concentrations of less well characterized metabolites. The use of a generic experimental macromolecule baseline provides a sufficiently accurate measurement of the neurochemical profile in rat brain.