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Abstract #0329

Optimisation of Oxygen-Enhanced Imaging in the Kidney

Katherine Frances Holliday1,2, Josephine H. Naish1,2, Jean Tessier3, Geoffrey J M Parker1,2

1Imaging Sciences, The University of Manchester, Manchester, United Kingdom; 2Biomedical Imaging Institute, Manchester, United Kingdom; 3Early Clinical Development, AstraZeneca, Macclesfield, United Kingdom

In this work we have optimised two sequences commonly used in Oxygen-Enhanced MRI (OE-MRI), Inversion-prepared Half Fourier Turbo Spin Echo (IR-HASTE) and Spoiled Gradient Echo (SPGR), for use in the kidneys. We then compared their abilities in vivo in a single subject. Finally we carried out a dynamic OE-MRI study in the kidneys of a small group of healthy volunteers. We showed that through the parameterisation of the dynamic signal curve obtained during gas switch-over, it is possible to create maps which distinguish between regions in the kidney with differing oxygen delivery.