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Abstract #0330

An Arterial Spin Labeling Approach to Kidney Perfusion: Assessing Reproducibility in Native and Transplanted Kidneys

Nathan S. Artz1, Elizabeth A. Sadowski2, Andrew L. Wentland1, Songwon Seo3, Arjang Djamali4, Sean B. Fain1,2

1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2Radiology, University of Wisconsin-Madison, Madison, WI, United States; 3Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, United States; 4Nephrology, University of Wisconsin-Madison, Madison, WI, United States


An ASL-FAIR approach was used to measure kidney perfusion in the cortex of 10 native kidneys and 15 transplanted kidneys in subjects with a wide range of kidney function. Exams were repeated within each visit and on two separate days and evaluated for reproducibility. The average within day Interclass Correlation Coefficient (ICC) was 0.93 with a Coefficient of Variation (CV) of 7.6% and the average between day ICC was 0.91 with a CV of 10.6%. This ASL method is reproducible in the cortex of the kidney. The data also provides guidelines for differentiating normal and abnormal perfusion variation during longitudinal assessment.