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Abstract #0335

Quantitative Magnetization Transfer Imaging of Human Brain at 3T Using Selective Inversion Recovery

Richard D. Dortch1,2, Ke Li1,2, Ashish A. Tamhane3, E B. Welch2,4, Dan F. Gochberg1,2, John C. Gore1,2, Seth A. Smith1,2

1Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States; 2Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 3Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States; 4MR Clinical Science, Philips Healthcare, Cleveland, OH, United States

Quantitative magnetization transfer (qMT) yields quantitative information about interactions between immobile macromolecular protons and free water protons. Because of its relatively short scan times, the pulsed, off-resonance saturation qMT approach is most commonly employed on clinical systems; however, it suffers from complicated data analysis and sensitivity to macromolecular proton lineshape assumptions. The selective inversion recovery (SIR) approach does not suffer from these shortcomings, but has not been widely implemented on clinical systems. In this study, the SIR approach was implemented on a clinical 3T system. The resultant qMT parameters in healthy brain were in good agreement with previously published values.