Meeting Banner
Abstract #0336

Magnetization Transfer Mapping of Myelinated Fiber Tracts in Living Mice at 9.4 T

Susann Boretius1, Peter Dechent2, Jens Frahm1, Gunther Helms2

1Biomedizinische NMR Forschungs GmbH, Max-Planck-Institut fr biophysikalische Chemie, Gttingen, Germany; 2MR-Research in Neurology and Psychiatry, University Medical Center, Gttingen, Germany

MRI of mouse models is an integral part of translational research on white matter diseases and myelin disorders. Thus, the delineation of myelinated fiber tracts in mice becomes of growing interest. Here we used in healthy adult mice a novel FLASH-based parameter for magnetization transfer that was recently established for human applications. In comparison to maps of MT ratio and T1, this parameter provides an improved gray-white matter contrast that allows for the visualization of small neuronal fiber bundles such as the mammilothalamic tract and fasciculus retroflexus.