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Abstract #0357

Specific Versus Nonspecific Connectivity: A Transition of the Resting Network from Light to Deep Anesthesia

Xiao Liu1,2, Xiao-Hong Zhu1, Yi Zhang1, Wei Chen1,2

1CMRR, radiology, University of Minnesota, Minneapolis, MN, United States; 2Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States

In this study, we observed that the resting networks covering specific rat cortical regions under light anesthesia (~1.0% isoflurane) merged into a nonspecific network covering wider cortical regions with stronger connectivity under the deep anesthesia (~1.8% isoflurane). This observation is consistent with a previous electrophysiological study, which demonstrated that the deeply anesthetized brain showed global and nonselective responses to external stimuli. They support a new theory in regards to anesthesia: the deep anesthesia can disrupt the repertoire of neural activity patterns and thus reduce the information carried by them, even though the information may still be integrated globally.