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Abstract #0362

A Novel MRI Method for Breast Cancer Detection Based on Diffusion Tensor Tracking of the Ductal Trees

Erez Eyal1, Myra Shapiro-Feinberg2, Edna Furman Haran1, Dov Grobgeld1, Talia Golan3, Yaakov Itzchak3, Raphael Catane3, Moshe Papa4, Hadassa Degani1

1Weizmann Institute of Science, Rehovot, Israel; 2Meir Medical Center, Kfar Saba, Israel; 3Sheba Medical Center, Tel Hashomer, Israel; 4Sheba Medical Center,, Tel Hashomer, Israel

Mammary malignancies typically develop from the ductal epithelial cells, and spread within the ducts. Consequently, the ductal structures are an important area of investigation of both normal breast development and malignant breast transformation. Our goal is to characterize the anisotropic water diffusion properties in the mammary ductal trees tissue using diffusion tensor MRI and to utilize this method to detect breast cancer. The results show that DTI based MRI reveals the diffusion anisotropy in the mammary ducts and can track changes in the diffusion tensor components due to cancer growth.