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Abstract #0363

Gadofosveset as a Negative Contrast Agent for Detecting Metastatic Axillary Lymph Nodes in Breast Cancer Patients on Diffusion and T2* Weighted Images - A Proof of Principle

Mies A. Korteweg1, Fredy Visser1,2, Daniel L. Polders1, Taro Takahara1, Willem P.Th.M. Mali1, Wouter B. Veldhuis1

1Radiology, University Medical Center Utrecht, Utrecht, Netherlands; 2Philips Healthcare, Best, Netherlands

This abstract describes the pathology-controlled, retrospective, gadofosveset-enhanced 3T MRI characterization of axillary lymph nodes in breast cancer patients. Gadofosveset was hypothesized to accumulate in a higher concentration in healthy than in metastatic nodes. It was shown that the mean absolute T2* relaxation time and the post contrast signal intensity of the lesion to spinal cord ratio on diffusion-weighted (DWI) scans were significantly higher in metastatic compared to non-metastatic nodes. The preliminary results suggest that gadofosveset increased the transverse relaxation rate in healthy nodes causing a negative contrast effect on DWI scans, selectively preserving the signal of metastatic lymph nodes.