Eric Edward
Sigmund1, Linda Moy1, Gene Cho1, Sungheon
Kim1, Myra Finn1, Jens Hesselberg Jensen1,
Melanie Moccaldi1, Daniel Sodickson1, Robert Schneider2,
Silvia Formenti3
1Radiology, New York University Langone
Medical Center, New York, NY, United States; 2Microbiology, New
York University Langone Medical Center, New York, NY, United States; 3Radiation
Oncology, New York University Langone Medical Center, New York, NY, United
States
Diffusion-weighted
imaging (DWI) is playing an increasing important role in breast cancer lesion
characterization, most commonly marking restricted diffusion in tumor
cellularity. Intravoxel incoherent
motion (IVIM) MRI is a DWI variant ideally providing markers not only of
cellularity, but also tumor vascularity and blood velocity. In this study we acquired IVIM data in N=25
breast cancer patients at 3 T and compared these markers with
contrast-enhanced MRI and biopsy diagnosis.
Robust quantification of the IVIM parameter set clearly differentiated
lesions from the weakly perfused normal fibroglandular tissue and may be
helpful for future quantitative lesion grading.