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Abstract #0368

Approaching Complete Separation of Benign and Malignant Breast Lesions by DCE-MRI: Impact on Healthcare Costs

Wei Huang1, Patricia A. Carney1, Luminita Alina Tudorica1, Yiyi Chen1, Xin Li1, Elizabeth A. Morris2, Ian J. Tagge1, Sunitha Thakur2, Maayan Korenblit2, Jason A. Koutcher2, Charles S. Springer1

1Oregon Health & Science University, Portland, OR, United States; 2Memorial Sloan Kettering Cancer Center, New York, NY, United States

Shutter-Speed Model (SSM) analyses of breast DCE-MRI data from 98 suspicious lesions show significantly improved diagnostic accuracy compared to Standard Model (SM) analyses and clinical MRI protocols. The difference in Ktrans derived from the two models, Ktrans [ Ktrans(SSM) C Ktrans(SM)], has near perfect specificity at 100% sensitivity. The cost effectiveness of replacing unnecessary benign biopsies with SSM DCE-MRI is significant.