Hyeon-Man
Baek1, Jeon-Hor Chen2,3, Orhan Nalcioglu2,
Min-Ying Su2
1Radiology, UT Southwestern Medical
Center, Dallas, TX, United States; 2Center for Function Onco-Imaging,
University of California-Irvine, Irvine, CA, United States; 3Radiology,
China Medical University Hospital, Taichung 404, Taiwan
ER-negative
cancer was more aggressive, with bigger tumor size, more prominent tumor
infiltration showing non-mass-type enhancements on magnetic resonance imaging
(MRI) features. The aim of our study was to determine whether in vivo 1H-MRS
can provide useful information for characterizing ER status in breast cancer.
On the basis of the criterion (i.e., CRB < 100%), tCho detection rate was
higher in ER-negative group (16/20, 80%) than in ER-positive group (15/27,
56%), but not reaching significant level (P = 0.083). The ER-positive group
had a lower mean tCho concentration than the ER-negative group, but no
significant difference was observed (2.01 vs. 2.24 mmol/kg, P = 0.677). The
reason why our finding was not significant might be due to the heterogeneity
of the breast cancer tissue.
Keywords