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Abstract #0373

13C MRS of Frontal Lobe at 3 Tesla Using a Volume Coil for Stochastic Proton Decoupling

Shizhe Steve Li1, Yang Zhang1, Shumin Wang1, Maria Ferraris Araneta1, Christopher S. Johnson1, Yun Xiang1, Robert B. Innis1, Jun Shen1

1National Institutes of Health, Bethesda, MD, United States

13C spectra from the frontal lobe of human brain were acquired for the first time at 3 Tesla. After intravenous infusion of [2-13C]glucose, glutamate, glutamine, and aspartate were detected in the carboxylic/amide carbons region. The RF power deposition was well below the safety guidelines, due to enhanced decoupling efficiency from the volume coil and weak J coupling between proton and carboxylic/amide carbons. The effect of the strong B0 field inhomogeneity in the frontal lobe region was reduced by RF coil arrangement and by a reference deconvolution technique that used the glutamate C5 peak as a lineshape reference.