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Abstract #0374

In Vivo detection of trans-Fatty Acids by 13C MRS at 7T

Ivan Dimitrov1,2, Jimin Ren2, Deborah Douglas2, A Dean Sherry2, Craig R. Malloy2

1Philips Medical Systems, Cleveland, OH, United States; 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

The severe health implications of trans-fats are well-known: their consumption leads to coronary heart disease, diabetes, cancer, liver dysfunction, and Alzheimers. We report the first non-invasive detection of trans-fats in humans by 13C MRS at 7T. WALTZ-16 decoupled FIDs with NOE were acquired from calves of healthy volunteers in 5 min. The allylic carbons (α to C=C) display substantially different chemical shifts (cis 27.18 vs. trans 32.59 ppm). A volunteer on a Western diet had a trans : cis ratio = 4.4 %, consistent with ex vivo reports, whereas no trans-fats were detected in a volunteer on a Mediterranean diet.