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Abstract #0375

Stimulated-Echo Contrast with Hyperpolarized [1-13C]-Pyruvate

Peder E. Z. Larson1, Ralph Hurd2, Adam B. Kerr3, Robert Bok1, John Kurhanewicz1, Daniel B. Vigneron1

1Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States; 2Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 3Electrical Engineering, Stanford University, Stanford, CA, United States

Stimulated-echoes can be used to provide high sensitivity to diffusion and flow, providing unique contrast. We have developed and applied stimulated-echo pulse sequences for hyperpolarized 13C metabolic imaging, studying both normal animals and the TRAMP prostate cancer mouse model to better distinguish the local metabolite environment. These experiments demonstrated a dramatic increase in CNR for tumors and present a new parameter for characterizing the metabolic state.