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Abstract #0381

In Vivo L-COSY MR Distinguishes Glutamate from Glutamine and Shows Neuropathic Pain to Cause a Buildup of Glutamine in the Brain

Alexander Peter Lin1, Saadallah Ramadan1, Peter Stanwell1, Tuan Luu1, James Celestin2, Zahid Bajwa2, Carolyn Mountford1

1Center for Clinical Spectroscopy, Brigham and Women's Hospital, Boston, MA, United States; 2Pain Management Center, Beth Israel Deaconess Medical Center, Boston, MA, United States

This study utilizes two-dimensional (2D) COrrelated SpectroscopY (COSY) to allow, in a clinically accepted time, detailed chemical information to be collected in situ from the brain. 2D COSY can in theory separate the glutamate and glutamine resonances by measuring distinct scalar coupling. These metabolites are neurotransmitters and affected by a number of diseases. For the first time we successfully distinguished between glutamine and glutamate using 2D COSY and show that glutamine is present in higher quantities in subjects with neuropathic pain.