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Abstract #0386

Contribution of Subpial Pathology to Cortical Thinning in Multiple Sclerosis: A Combined 7T - 3T MRI Study.

Caterina Mainero1, Thomas Benner1, Amy Radding1, Andre van der Kouwe1, R Philip Kinkel2, Bruce R. Rosen1

1A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; 2Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States

In multiple sclerosis (MS) it is unclear whether cortical atrophy is secondary to white matter (WM) damage, or underlies a primary neuronal process. Here, we investigate the contribution of different cortical lesions types at 7T and WM lesion load (WMLL) to cortical thinning in 14 MS patients. The higher the number of all cortical lesions, and of type III/IV lesions (subpial lesions extending partly or completely through the cortical width) the thinner the cortex was. There was only a trend to significance for WMLL. Thinning in frontal cortical areas showed the highest correlation with type III/IV lesions. Subpial pathology is a major determinant of cortical atrophy in MS.