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Abstract #0387

Grey Matter Perfusion Is Inversely Correlated to T2 Lesion Load in MS Patients - A 3D GRASE Arterial Spin Labeling Study at 1.5T

Michael Amann1, Jochen Gunther Hirsch1, Lutz Achtnichts2, Yvonne Naegelin2, Johannes Gregori3, Martin Schaellebaum2, Katrin Weier2, Alain Thni, Ernst Wilhelm Radue, Matthias Gnther3, Ludwig Kappos2, Achim Gass1

1Neurology/Neuroradiology, University Hospital, Basel, BS, Switzerland; 2Neurology, University Hospital, Basel, BS, Switzerland; 3MR Research Neurology, University Hospital, Mannheim, BW, Germany

We investigated the influence of different clinical and MRI factors onto grey matter (GM) perfusion in MS patients (123 RRMS, 42 SPMS, 7 PPMS, and 5 CIS). To assess cerebral blood flow (CBF), we applied a pulsed arterial spin labeling technique combined with single-shot 3D-GRASE readout. The mean GM-CBF in each patient was calculated for 10 supratentorial slices. Multiple linear regression models were calculated to investigate the relationship between different factor sets and mean GM-CBF. Post-hoc Spearman rank correlation revealed significant correlation of GM-CBF with T2 lesion load (p=2*10-6) and with age (p=0.002), but neither with GM-atrophy nor disease onset.