Michael Amann1, Jochen Gunther Hirsch1, Lutz Achtnichts2, Yvonne Naegelin2, Johannes Gregori3, Martin Schaellebaum2, Katrin Weier2, Alain Thni, Ernst Wilhelm Radue, Matthias Gnther3, Ludwig Kappos2, Achim Gass1
1Neurology/Neuroradiology, University Hospital, Basel, BS, Switzerland; 2Neurology, University Hospital, Basel, BS, Switzerland; 3MR Research Neurology, University Hospital, Mannheim, BW, Germany
We investigated the influence of different clinical and MRI factors onto grey matter (GM) perfusion in MS patients (123 RRMS, 42 SPMS, 7 PPMS, and 5 CIS). To assess cerebral blood flow (CBF), we applied a pulsed arterial spin labeling technique combined with single-shot 3D-GRASE readout. The mean GM-CBF in each patient was calculated for 10 supratentorial slices. Multiple linear regression models were calculated to investigate the relationship between different factor sets and mean GM-CBF. Post-hoc Spearman rank correlation revealed significant correlation of GM-CBF with T2 lesion load (p=2*10-6) and with age (p=0.002), but neither with GM-atrophy nor disease onset.