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Abstract #0399

Theranostic Imaging of Metastatic Disease

Zhihang Chen1, Marie-France Penet1, Sridhar Nimmagadda1, Cong Li1, Sangeeta Ray1, Paul Winnard1, Dmitri Artemov1, Kristine Glunde1, Martin G. Pomper1, Zaver M. Bhujwalla1

1JHU ICMIC Program, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

There is a compelling need to find effective treatments for metastatic disease, as it typically becomes refractory to treatment. We are developing targeted nanoplexes carrying multimodality imaging reporters together with small interfering RNA (siRNA) and a prodrug enzyme for theranostic imaging of metastatic prostate cancer. Down-regulation of specific pathways using siRNA provides unique opportunities to target cancer cells selectively while sparing normal tissue. The targeted nanoplexes we develop will allow us to deliver siRNA together with a prodrug enzyme, under image guidance for developing theranostic imaging of metastatic prostate cancer.