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Abstract #0434

fMRI and Dynamic Causal Modeling Reveal Inefficient and Imbalanced Network Interactions in Developmentally Vulnerable Adolescents

Vaibhav A. Diwadkar1,2, Neil Bakshi1, Patrick Pruitt1, Ashu Kaushal3, Eric R. Murphy4, Matcheri S. Keshavan5, Usha Rajan3, Caroline Zajac-Benitez3

1Psychiatry & Behavioral Neuroscience, Wayne State University SOM, Detroit, MI, United States; 2Psychiatry, University of Pittsburgh SOM, Pittsburgh, PA, United States; 3Psychiatry, Wayne State University SOM, Detroit, MI, United States; 4Psychology, Georgetown University, Washington, DC, United States; 5Psychiatry, Beth Israel Deaconness Medical Center, Boston, MA, United States

We used fMRI and dynamic causal modeling to study altered functional organization of sustained attention networks in adolescent offspring of schizophrenia patients. This group is at increased risk for psychiatric disorders, demonstrating impairments in cognitive function, making it an important one in whom to study developmental vulnerabilities. Modeling focused on interactions between control systems such as the anterior cingulate cortex, and frontal, parietal and striatal regions. Offspring evinced reduced cingulate-striatal coupling, but increased cingulate-prefrontal coupling. Reduced cortico-striatal coupling, along with increased cortico-cortical coupling may reflect the impact of abnormal development on the role of control processes in the adolescent brain.