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Abstract #0435

Short-Term Effects of Antipsychotic Treatment on Cerebral Function in Drug-Naive First-Episode Schizophrenia Revealed by RfMRI

Su Lui1, Tao Li, Wei Deng, Lijun Jiang, Qizhu Wu1, Hehan Tang1, Qiang Yue1, Xiaoqi Huang1, Raymond C. Chan2, David A Collier3, Shashwath A. Meda4, Godfrey Pearlson4, Andrea Mechelli3, John A. Sweeney5, Qiyong Gong1

1Huaxi MR Research Center, West China Hospital, Chengdu, Sichuan, China; 2Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Bei Jin, China; 3Institute of Psychiatry King's College London, London, United Kingdom; 4Neuropsychiatry Research Center, Institute of Living, Hartford, United States; 5Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, United States

Amplitude of low-frequency fluctuations in conjunction with the analysis of the resting state functional connectivity was applied to both regional cerebral function and functional integration in drug-naive schizophrenia patients before and after pharmacotherapy. Thirty-four antipsychotic-naive first-episode schizophrenia patients and 34 age, sex, height, weight, handedness and years of education matched controls were scanned using an EPI sequence on a 3T MR imaging system. Patients were rescanned after six weeks treatment. For first time, we characterized that widespread increased regional synchronous neural activity occurs after antipsychotic therapy, accompanied with decreased integration of function across widely distributed neural networks.