Su Lui1, Tao Li, Wei Deng, Lijun Jiang,
Qizhu Wu1, Hehan Tang1, Qiang Yue1, Xiaoqi
Huang1, Raymond C. Chan2, David A Collier3,
Shashwath A. Meda4, Godfrey Pearlson4, Andrea Mechelli3,
John A. Sweeney5, Qiyong Gong1
1Huaxi MR Research Center, West China
Hospital, Chengdu, Sichuan, China; 2Neuropsychology and Applied
Cognitive Neuroscience Laboratory, Institute of Psychology, Bei Jin, China; 3Institute
of Psychiatry King's College London, London, United Kingdom; 4Neuropsychiatry
Research Center, Institute of Living, Hartford, United States; 5Center
for Cognitive Medicine, University of Illinois at Chicago, Chicago, United
States
Amplitude
of low-frequency fluctuations in conjunction with the analysis of the resting
state functional connectivity was applied to both regional cerebral function
and functional integration in drug-naive schizophrenia patients before and
after pharmacotherapy. Thirty-four
antipsychotic-naive first-episode schizophrenia patients and 34 age, sex,
height, weight, handedness and years of education matched controls were
scanned using an EPI sequence on a 3T MR imaging system. Patients were
rescanned after six weeks treatment.
For first time, we characterized that widespread increased regional
synchronous neural activity occurs after antipsychotic therapy, accompanied
with decreased integration of function across widely distributed neural
networks.
Keywords